Triethylamine → 3-(Azetidin-1-ylcarbonyl)-6-chloropyridazine

Temperature

0 °C

Phosphorus oxychloride (50 mL) was added to 6-hydroxypyridazine-3-carboxylic acid (9.82 g, 70.05 mmol) and the resulting solution heated to reflux. After 45 mins the solution was allowed to cool and the excess of phosphorus oxychloride was removed under reduced pressure. THF (50 mL) was added to the black residue and the resulting solution cooled to 0° C. Triethylamine (9.77 mL, 70.05 mmol) and azetidine (4.0 g, 70.05 mmol) were added dropwise. The resulting mixture was allowed to warm to RT and stirred overnight. The volatiles were removed under reduced pressure and water (50 mL) added, then the residue was adjusted to pH8 using sodium hydroxide solution. The aqueous layer was extracted five times with ethyl acetate, the combined organics dried (MgSO4) and the solvent removed to give the crude product as a dark oil. A sample was purified by preparative HPLC, eluting with 5-95% acetonitrile in water (+0.2% TFA), and gave the title compound as a colorless solid (135 mg).

1. temperaturethe resulting solution heated to reflux
2. temperatureto cool
3. customthe excess of phosphorus oxychloride was removed under reduced pressure
4. additionTHF (50 mL) was added to the black residue
5. temperatureto warm to RT
6. customThe volatiles were removed under reduced pressure and water (50 mL)
7. additionadded
8. extractionThe aqueous layer was extracted five times with ethyl acetate
9. dry with materialthe combined organics dried (MgSO4)
10. customthe solvent removed
11. customto give the crude product as a dark oil
12. customA sample was purified by preparative HPLC
13. washeluting with 5-95% acetonitrile in water (+0.2% TFA)

ORD record

ord-298c464fbd0647f1958d09b9434dae84

Source dataset

uspto-grants-2010_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07642259B2