1,1,3,3-Tetramethylguanidine → HCID 67397587, compound

HRID 1990700Notes

Reaction equation

HRID 1990700 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7]1.[O:15]1[CH2:19][C:18](=[O:20])[NH:17][C:16]1=[O:21].CN(C)C(N(C)C)=N>O1CCCC1>[N:6]1([CH2:5][CH2:4][CH2:3][CH2:2][N:17]2[C:18](=[O:20])[CH2:19][O:15][C:16]2=[O:21])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7]1

Participants

5

Reactant 3

HCID 664601,1,3,3-TetramethylguanidineHCID 973892,4-OxazolidinedioneHCID 13340133HCID 13340133, compound

Product 1

HCID 67397587HCID 67397587, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3 g (11.90 mmol) of 1-(4-bromobutyl)-1H-indole, prepared in stage 2.1., of 2.41 g (23.80 mmol) of 1,3-oxazolidin-2,4-dione (J. Med. Chem., 1991, 34, 1538-1544) and of 2.74 g (23.80 mmol) of 1,1,3,3-tetramethylguanidine in 30 ml of tetrahydrofuran is brought to reflux for 14 hours under an inert atmosphere.

Workup

  1. temperatureto reflux for 14 hours under an inert atmosphere

Sources & evidence

ORD record
ord-f10e43c407044bfcb8a90169a70605d9
Source dataset
uspto-grants-2010_01
Patent number
US07645757B2

Reaction notes

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