Methanol → HCID 59128612, compound

HRID 1990701Notes

Reaction equation

HRID 1990701 reaction equation
[N:1]1([CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[C:18](=[O:19])[CH2:17][O:16][C:15]2=[O:20])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[CH3:21][NH2:22].ClCCl.CO>O1CCCC1>[N:1]1([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15](=[O:20])[O:16][CH2:17][C:18]([NH:22][CH3:21])=[O:19])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

6

Reactant 4

HCID 887MethanolHCID 6329MethylamineHCID 6344DichloromethaneHCID 67397587HCID 67397587, compound

Product 1

HCID 59128612HCID 59128612, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The procedure is as described in Example 1 (stage 1.4.). Starting from 0.90 g (3.31 mmol) of 3-[4-(1H-indol-1-yl)butyl]-1,3-oxazolidine-2,4-dione, obtained in stage 2.2., and from 5 ml (9.93 mmol) of a solution of methylamine (2M) in tetrahydrofuran, and after chromatography on silica gel, elution being carried out with a 98/2 mixture of dichloromethane and of methanol, 0.70 g of product is obtained in the form of an amorphous white solid.

Workup

  1. customobtained in stage 2.2

Sources & evidence

ORD record
ord-e86780e0f76c4f8ab204a43e1eda723e
Source dataset
uspto-grants-2010_01
Patent number
US07645757B2

Reaction notes

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