Hydrogen Bromide → HCID 178419736, compound

HRID 1990793Notes

Reaction equation

HRID 1990793 reaction equation
[BrH:1].C[O:3][C:4]1[N:9]=[CH:8][C:7]([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]3=[N:20][N:21]=[CH:22][N:12]3[N:11]=2)=[CH:6][CH:5]=1>>[BrH:1].[N:20]1[N:21]=[CH:22][N:12]2[N:11]=[C:10]([C:7]3[CH:6]=[CH:5][C:4]([OH:3])=[N:9][CH:8]=3)[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]=12

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 23153667HCID 23153667, compound

Product 1

HCID 178419736HCID 178419736, compound

Procedure

47% hydrobromic acid was added to 141 mg of 6-(6-methoxypyridin-3-yl)-[1,2,4]triazolo[3,4-a]phthalazine, and refluxed for 4 hours. The reaction liquid was concentrated under reduced pressure, and ether was added to the resulting residue. The resulting solid was taken out through filtration to obtain 250 mg of 5-[1,2,4]triazolo[3,4-a]phthalazin-6-ylpyridin-2-ol hydrobromide as a brown solid.

Workup

  1. temperaturerefluxed for 4 hours
  2. customThe reaction liquid
  3. concentrationwas concentrated under reduced pressure, and ether
  4. additionwas added to the resulting residue
  5. filtrationThe resulting solid was taken out through filtration

Sources & evidence

ORD record
ord-13c05ec6216a4439b73e2baaa87efa77
Source dataset
uspto-grants-2010_01
Patent number
US07645756B2

Reaction notes

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