反应详情

To a solution of 2-amino-5-ethoxy-4-trifluoromethyl-benzonitrile (31.62 g, 137.4 mmol, 1.0 equiv) in anhydrous THF (410 mL) was added isoamyl nitrite (40.4 mL, 302 mmol, 2.2 equiv) and the mixture was heated to reflux for 16 h. The solvent was removed by evaporation under reduced pressure to give an orange oil which was dissolved in a sat. solution of NaHCO3 and extracted three times with diethyl ether. The combined organic phases were washed with 1 N HCl and a sat. solution of sodium chloride and the organic phases dried over Na2SO4. Removal of the solvent by evaporation under reduced pressure left an orange oil which was purified by double Kugelrohr distillation (up to 160° C. bath temperature at 1.5 mbar) yielding 25.1 g (85%) of the title compound as a light yellow solid upon solidification. MS (EI): 185.1 [M]+.

1. temperaturethe mixture was heated
2. temperatureto reflux for 16 h
3. customThe solvent was removed by evaporation under reduced pressure
4. customto give an orange oil which
5. extractionextracted three times with diethyl ether
6. washThe combined organic phases were washed with 1 N HCl
7. dry with materiala sat. solution of sodium chloride and the organic phases dried over Na2SO4
8. customRemoval of the solvent
9. customby evaporation under reduced pressure
10. waitleft an orange oil which
11. distillationwas purified by double Kugelrohr distillation (up to 160° C. bath temperature at 1.5 mbar)