4-Aminotetrahydropyran → HCID 24789143, compound

HRID 1991015Notes

Reaction equation

[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]([CH3:26])=[C:10]([C:12]2[C:23](=[O:24])[N:22]([CH3:25])[C:15]3[N:16]=[C:17](SC)[N:18]=[CH:19][C:14]=3[CH:13]=2)[CH:11]=1.OOS([O-])=O.[K+].[NH2:33][CH:34]1[CH2:39][CH2:38][O:37][CH2:36][CH2:35]1>>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]([CH3:26])=[C:10]([C:12]2[C:23](=[O:24])[N:22]([CH3:25])[C:15]3[N:16]=[C:17]([NH:33][CH:34]4[CH2:39][CH2:38][O:37][CH2:36][CH2:35]4)[N:18]=[CH:19][C:14]=3[CH:13]=2)[CH:11]=1

Participants

Reactant 3

HCID 4192234-Aminotetrahydropyran

HCID 23707502Potassium hydroxy sulfite

HCID 59128646HCID 59128646, compound

Product 1

HCID 24789143HCID 24789143, compound

Procedure

6-[5-(1H-Imidazol-2-yl)-2-methyl-phenyl]-8-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one was treated with OXONE™ following the procedure of step 3 of Example 1, and the resulting sulfonyl compound was treated with 4-amino-tetrahydropyran using the procedure of step 4 of Example 1, to give 2.5 mg of 6-[5-(1H-imidazol-2-yl)-2-methyl-phenyl]-8-methyl-2-(tetrahydro-pyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one: MS (M+H)=417.

Sources & evidence

ORD record: ord-1150397c839d47c19580b5ec9baeb7e7
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07645764B2

Reaction notes

Loading…