HCID 59128690, compound → HCID 59128706, compound

HRID 1991143Notes

Reaction equation

HRID 1991143 reaction equation
[C:1]1(=[CH:7][C:8]2[CH:9]=[C:10]3[C:16]([C:17]4[CH:18]=[N:19][N:20]([CH3:22])[CH:21]=4)=[CH:15][N:14]([S:23]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)(=[O:25])=[O:24])[C:11]3=[N:12][CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>CO.[OH-].[OH-].[Pd+2]>[CH:1]1([CH2:7][C:8]2[CH:9]=[C:10]3[C:16]([C:17]4[CH:18]=[N:19][N:20]([CH3:22])[CH:21]=4)=[CH:15][N:14]([S:23]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)(=[O:25])=[O:24])[C:11]3=[N:12][CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 59128690HCID 59128690, compound

Product 1

HCID 59128706HCID 59128706, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

A mixture of 96 (32 mg, 0.073 mmol) and Pd(OH)2 (1.0 mg, 7.3 μmol) in MeOH (2.0 mL) was stirred under H2 at r.t. for 30.5 h. The mixture was filtered through Celite and concentrated to afford 97, which was used in the next step without purification.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-58326b8d41ae4f61a5d37376fe6aabfa
Source dataset
uspto-grants-2010_01
Patent number
US07645769B2

Reaction notes

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