Diisopropylamine → HCID 137227822, compound

HRID 1991398Notes

Reaction equation

HRID 1991398 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[C@@H:13]([C:14]([OH:16])=O)[CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].F[P-](F)(F)(F)(F)F.CN(C(=[N+](C)C)ON1C2=NC=CC=C2N=N1)C.C(NC(C)C)(C)C.[OH:48][NH:49][C:50](=[NH:59])[C:51]1[CH:56]=[CH:55][C:54]([O:57][CH3:58])=[CH:53][CH:52]=1>CN(C)C=O>[C:2]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH2:11][CH2:12][C@@H:13]1[C:14](=[O:16])[NH:59][C:50](=[N:49][OH:48])[C:51]1[CH:52]=[CH:53][C:54]([O:57][CH3:58])=[CH:55][CH:56]=1)=[O:7])([CH3:1])([CH3:3])[CH3:4]

Participants

6

Reactant 4

HCID 7912DiisopropylamineHCID 688618(2R)-1-[(tert-butoxy)carbonyl]piperidine-2-carboxylic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 178491258HCID 178491258, compound

Product 1

HCID 137227822HCID 137227822, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

23 mg (0.1 mmol) of Boc-D-Pipecolic Acid were treated with 0.1 mmol [Dimethylamino-([1,2,3]triazolo[4,5-b]pyridin-3-yloxy)-methylene]-dimethyl-ammonium hexafluorophosphate (HATU) and Diisopropylamine (DIPEA) in 1 ml Dimethylforamide (DMF) for 10 min. 17 mg (0.1 mmol) of N-Hydroxy-4-methoxy-benzamidine were added and the reaction stirred at room temperature for 20 min. The product was not further characterized.

Sources & evidence

ORD record
ord-a120ba423126409eb80bdc6d46562a2d
Source dataset
uspto-grants-2010_01
Patent number
US07645776B2

Reaction notes

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