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HRID1991400

反应详情

EQUATION

反应方程式

HRID 1991400 的结构方程式

REACTANTS

反应物

5
结构：O=C(O)COc1ccccc1
HCID19188

Phenoxyacetic acid

C8H8O3

结构：O=C(Cl)COc1ccccc1
HCID69703

Acetyl chloride, phenoxy-

C8H7ClO2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：COc1ccc(-c2noc([C@H]3CCCCN3)n2)cc1.O=C(O)C(F)(F)F
HCID68687777

未命名化合物

2 次

结构：CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID86612873

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(-c2noc([C@H]3CCCCN3C(=O)COc3ccccc3)n2)cc1
HCID16736346

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

PROCEDURE

实验过程

Crude material from step 3 was dissolved in 1 ml DMF and 0.1 mmol DIPEA. Either 0.1 mmol phenoxyacetyl chloride were added and the reaction stirred at room temperature for 30 min, or the corresponding phenoxyacetic acid derivatives were pre-activated with HATU/DIPEA in DMF for lOmin and added to the crude material from step 3. The product was isolated via preparative high performance liquid chromatography (HPLC).

WORKUP

后处理

  1. customThe product was isolated via preparative high performance liquid chromatography (HPLC)