Methyl iodide → HCID 68690101, compound

HRID 1991401Notes

Reaction equation

HRID 1991401 reaction equation
[O:1]([CH2:8][C:9]([N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH:12]1[C:17]1[O:21][N:20]=[C:19]([C:22]2[CH:30]=[CH:29][C:25]([C:26]([NH2:28])=[O:27])=[CH:24][CH:23]=2)[N:18]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:31]CN(C(C)C)C(C)C.C([O-])([O-])=O.[Na+].[Na+].CI>CN(C=O)C>[CH3:31][N:14]1[CH2:15][CH2:16][N:11]([C:9](=[O:10])[CH2:8][O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:12]([C:17]2[O:21][N:20]=[C:19]([C:22]3[CH:23]=[CH:24][C:25]([C:26]([NH2:28])=[O:27])=[CH:29][CH:30]=3)[N:18]=2)[CH2:13]1

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 10340Sodium CarbonateHCID 81531DiisopropylethylamineHCID 68687017HCID 68687017, compound

Product 1

HCID 68690101HCID 68690101, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.1 mmol of 4-{5-[1-(2-Phenoxy-acetyl)-piperazin-2-yl]-[1,2,4]oxadiazol-3-yl}-benzamide are dissolved in 1 ml DMF and 1 eq. DIPEA and Na2CO3 added. To the suspension 1 eq. of MeI is added and the reaction stirred at room temperature overnight. The product is isolated via preparative HPLC.

Workup

  1. customThe product is isolated via preparative HPLC

Sources & evidence

ORD record
ord-90d6ae37cab9468698b4604d4462d6f3
Source dataset
uspto-grants-2010_01
Patent number
US07645776B2

Reaction notes

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