Acetyl chloride → N-(5-Cyanopyridin-2-yl)acetamide
Reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1.CCN(C(C)C)C(C)C.[C:19](Cl)(=[O:21])[CH3:20].C(OC(=O)C)C.O>C1COCC1>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([NH:1][C:19](=[O:21])[CH3:20])=[N:3][CH:4]=1)#[N:7]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
8 mmol of 6-Amino-nicotinonitrile were dissolved in THF. 2 eq of DIPEA were added. The reaction mixture was cooled to 0° C. and 1.0 eq of acetylchloride in THF added dropwise and the reaction stirred for 2 h. The product was isolated by extraction from ethylacetate/water.
Sources & evidence
- ORD record
- ord-85b1c05f7c4747cfbfe358b25891760f
- Source dataset
- uspto-grants-2010_01
- Patent number
- US07645776B2
Reaction notes
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