Acetyl chloride → N-(4-Cyanopyridin-2-yl)acetamide
Reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][N:9]=1)[C:5]#[N:6].CCN(C(C)C)C(C)C.[C:19](Cl)(=[O:21])[CH3:20].C(OC(=O)C)C.O>C1COCC1>[C:5]([C:4]1[CH:7]=[CH:8][N:9]=[C:2]([NH:1][C:19](=[O:21])[CH3:20])[CH:3]=1)#[N:6]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
8 mmol of 2-Amino-isonicotinonitrile were dissolved in THF. 2 eq of DIPEA were added. The reaction mixture was cooled to 0° C. and 1.0 eq of acetylchloride in THF added dropwise and the reaction stirred for 2 h. The product was isolated by extraction from ethylacetate/water.
Sources & evidence
- ORD record
- ord-6d59a6dcbf51452490cfff4114391d7d
- Source dataset
- uspto-grants-2010_01
- Patent number
- US07645776B2
Reaction notes
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