Diethylamine → HCID 68691864, compound

HRID 1991484Notes

Reaction equation

HRID 1991484 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[N:12]([CH:13]([CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[C:14]([NH:16][CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)=[O:15])[C:11]3[CH:29]=[CH:30][CH:31]=[CH:32][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.[CH2:33]([NH:35][CH2:36][CH3:37])[CH3:34]>CN(C=O)C>[CH:23]1([CH:13]([N:12]2[C:11]3[CH:29]=[CH:30][CH:31]=[CH:32][C:10]=3[N:9]=[C:8]2[C:5]2[CH:6]=[N:7][C:2]([N:35]([CH2:36][CH3:37])[CH2:33][CH3:34])=[CH:3][CH:4]=2)[C:14]([NH:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:15])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 86617977HCID 86617977, compound

Product 1

HCID 68691864HCID 68691864, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
120 °C

Procedure

90 mg of 2-[2-(6-Chloro-pyridin-3-yl)-benzoimidazol-1-yl]-2,N-dicyclohexyl-acetamide (example 189) (0.2 mmol, 1 equiv.) were dissolved in DMF (1 ml). 102 ul (1 mmol, 5 equiv.) of diethylamine are added. The mixture was heated to 120° C. for 15 min using microwave heating). The product was isolated via preperative HPLC. MS (ES+): 489 (M+H).

Workup

  1. temperatureusing microwave heating)
  2. customThe product was isolated via preperative HPLC

Sources & evidence

ORD record
ord-4dfd3c55fbcc49168fc2d09c38bc0f5b
Source dataset
uspto-grants-2010_01
Patent number
US07645785B2

Reaction notes

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