反应详情

2.2 g (6.65 mmol) 1-(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)-2-methyl-1H-benzimidazole was dissolved in 150 ml ethanol and 2.09 g (33.23 mmol) ammonium formate and 0.4 g palladium hydroxide (20% on carbon) were added. The mixture was refluxed for 2.5 hrs. The mixture was cooled to ambient temperature and filtered through celite. The solvent was removed under reduced pressure and the crude product was purified by column chromatography CH2Cl:CH3OH:NH4OH (95:5:0.5) to afford 1.06 g of the desired product as a solid.

1. temperatureThe mixture was refluxed for 2.5 hrs
2. filtrationfiltered through celite
3. customThe solvent was removed under reduced pressure
4. customthe crude product was purified by column chromatography CH2Cl:CH3OH:NH4OH (95:5:0.5)