Hydrochloric Acid → HCID 86608475, compound

HRID 1992190Notes

Reaction equation

HRID 1992190 reaction equation
[Cl:1][C:2]1[C:11]([NH:12][S:13]([C:16]([F:19])([F:18])[F:17])(=[O:15])=[O:14])=[CH:10][C:9]([Cl:20])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+].Cl>CO>[ClH:1].[Cl:1][C:2]1[C:11]([NH:12][S:13]([C:16]([F:19])([F:17])[F:18])(=[O:14])=[O:15])=[CH:10][C:9]([Cl:20])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58728581HCID 58728581, compound

Product 1

HCID 86608475HCID 86608475, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Crude methyl 2,5-dichloro-3-{[(trifluoromethyl) sulfonyl]amino}benzoate (4.0 g) was dissolved in methanol (30 ml) and 4N NaOH (30 ml) was added while stirring at room temperature for 18 hrs. Removed solvent and added 4N HCl (10 ml). Stirred at room temperature for 4 hours. Filtered off solid to give 2,5-dichloro-3-{[(trifluoromethyl) sulfonyl]amino}benzoic acid hydrochloride in quantitative yield.

Workup

  1. stirringStirred at room temperature for 4 hours
  2. filtrationFiltered off solid

Sources & evidence

ORD record
ord-1760d859c53c490999605a2e2098870e
Source dataset
uspto-grants-2010_01
Patent number
US07645771B2

Reaction notes

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