Hydrochloric Acid → HCID 131727847, compound

HRID 1992334Notes

Reaction equation

HRID 1992334 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]1[CH2:17][CH:16]2[O:18][CH:12]([CH2:13][N:14]([CH2:19][CH2:20][CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][CH:24]=3)[CH2:15]2)[CH2:11]1)(C)(C)C.[ClH:32]>O1CCOCC1>[ClH:32].[NH2:7][CH2:8][CH2:9][N:10]1[CH2:11][CH:12]2[O:18][CH:16]([CH2:15][N:14]([CH2:19][CH2:20][CH2:21][O:22][C:23]3[CH:24]=[CH:25][C:26]([C:29]#[N:30])=[CH:27][CH:28]=3)[CH2:13]2)[CH2:17]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9802767HCID 9802767, compound

Product 1

HCID 131727847HCID 131727847, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(2-{7-[3-(4-Cyanophenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}-ethyl)carbamic acid tert-butyl ester (4.5 g, 0.0104 mol; see step (i) above) was added to a solution of HCl in dioxane. The reaction was stirred at room temperature for 2 h, after which the reaction mixture was filtered and the resultant solid washed with dioxane, then diethyl ether and dried to give the title compound (3.89 g) as a white solid.

Workup

  1. filtrationafter which the reaction mixture was filtered
  2. washthe resultant solid washed with dioxane
  3. dry with materialdiethyl ether and dried

Sources & evidence

ORD record
ord-76b8d69365db4bbcb4cc8a7f95ccdb15
Source dataset
uspto-grants-2010_01
Patent number
US07648985B2

Reaction notes

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