Hydrochloric Acid → HCID 131727849, compound

HRID 1992352Notes

Reaction equation

HRID 1992352 reaction equation
[ClH:1].C(OC([N:9]1[CH2:16][CH:15]2[O:17][CH:11]([CH2:12][N:13]([CH2:18][CH2:19][NH:20][S:21]([C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)(=[O:23])=[O:22])[CH2:14]2)[CH2:10]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[F:30][C:27]1[CH:28]=[CH:29][C:24]([S:21]([NH:20][CH2:19][CH2:18][N:13]2[CH2:14][CH:15]3[O:17][CH:11]([CH2:10][NH:9][CH2:16]3)[CH2:12]2)(=[O:23])=[O:22])=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68523343HCID 68523343, compound

Product 1

HCID 131727849HCID 131727849, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

HCl in dioxane (50 ml) was added to a solution of 7-[2-(4-Fluoro-benzenesulfonylamino)-ethyl]-9-oxa-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (4 g; see step (ii) above) in dry dioxane (50 ml) at RT and the reaction mixture was stirred at RT for 1 h. Dioxane was decanted, precipitated solid was washed with dry diethyl ether (three times) and dried under vacuum to give the title compound as pale yellow solid. Yield: 3.55 g

Workup

  1. customDioxane was decanted
  2. customprecipitated solid
  3. washwas washed with dry diethyl ether (three times)
  4. customdried under vacuum

Sources & evidence

ORD record
ord-413f666a4b9340a596d8ee2edb1b990e
Source dataset
uspto-grants-2010_01
Patent number
US07648985B2

Reaction notes

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