Hydrochloric Acid → 2-(3,4-Difluorophenyl)acetaldehyde
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][O:10]C)=[CH:4][C:3]=1[F:12].Cl>CC(C)=O>[F:12][C:3]1[CH:4]=[C:5]([CH2:8][CH:9]=[O:10])[CH:6]=[CH:7][C:2]=1[F:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 45 °C
Procedure
To a solution of 1,2-difluoro-4-(2-methoxy-vinyl)-benzene (5.5 g, 0.032 mol, from step (i) above) in 80 ml acetone was added 66 ml of 3 (M) HCl and stirred at 45° C. for 4 h. Acetone was evaporated under reduced pressure and the residue was
Workup
- customAcetone was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-03a39ec233bd4b9b9046549dcbae6da1
- Source dataset
- uspto-grants-2010_01
- Patent number
- US07648985B2
Reaction notes
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