反应详情

温度

80 °C

A mixture of 2,5-difluorophenol (2.60 g, 20.0 mmol), 1,3-dibromopropane (20.3 mL, 200 mmol), and potassium carbonate (2.76 g, 20.0 mmol) in acetonitril (30 mL) was heated at 80° C. overnight. The reaction mixture was filtered and the filtrate was concentrated in vacuo to give 4.82 g of the title compound as a light yellow oil with a purity of ca. 80%. The product was used in the subsequent reaction step without further purification.

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate was concentrated in vacuo