Hydrochloric Acid → HCID 86598852, compound

HRID 1992450Notes

Reaction equation

HRID 1992450 reaction equation
[F:1][C:2]([F:42])([F:41])[C:3]1[CH:4]=[C:5]([C@H:13]([N:15]([CH3:40])[C:16]([N:18]2[CH2:23][CH2:22][C@H:21]([N:24]3[CH2:29][CH2:28][N:27]([C:30](=[O:32])[CH3:31])[CH2:26][CH2:25]3)[CH2:20][C@@H:19]2[C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=2)=[O:17])[CH3:14])[C:6](C(F)(F)F)=[CH:7][CH:8]=1.[ClH:43]>CCOCC>[ClH:43].[F:1][C:2]([F:41])([F:42])[C:3]1[CH:4]=[C:5]([C@H:13]([N:15]([CH3:40])[C:16]([N:18]2[CH2:23][CH2:22][C@H:21]([N:24]3[CH2:25][CH2:26][N:27]([C:30](=[O:32])[CH3:31])[CH2:28][CH2:29]3)[CH2:20][C@@H:19]2[C:33]2[CH:34]=[CH:35][C:36]([F:39])=[CH:37][CH:38]=2)=[O:17])[CH3:14])[CH:6]=[C:7]([C:2]([F:42])([F:41])[F:1])[CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86761039HCID 86761039, compound

Product 1

HCID 86598852HCID 86598852, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 18b (20 mg) in dry Et2O (1 mL) was treated at −8° C. with hydrochloric acid (1M in Et2O—0.5 mL). The resulting mixture was stirred at 0° C. for 10 minutes, then filtered; the filtrate was triturated with dry pentane (2×2 mL) to give the title compound as a whitish solid (14.7 mg).

Workup

  1. filtrationfiltered
  2. customthe filtrate was triturated with dry pentane (2×2 mL)

Sources & evidence

ORD record
ord-3b000301dbb942a7a7af3536f00cad3a
Source dataset
uspto-grants-2010_01
Patent number
US07648990B2

Reaction notes

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