Dimethylformamide → tert-butyl 3-(5-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1H,3H,5H)-yl)piperidine-1-carboxylate

HRID 199253Notes

Reaction equation

HRID 199253 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([NH:14][CH2:15][c:16]2[cH:17][nH:18][c:19]3[n:20][cH:21][cH:22][c:23]([C:25](=[O:26])[OH:27])[c:24]23)[CH2:11][CH2:12][CH2:13]1.[CH3:57][N:58]([c:59]1[cH:60][cH:61][n:62][cH:63][cH:64]1)[CH3:65].[O:52]=[CH:53][N:54]([CH3:55])[CH3:56].[P-:28]([F:29])([F:30])([F:31])([F:32])([F:33])[F:34].[n:35]1([O:36][C:37]([N:38]([CH3:39])[CH3:40])=[N+:41]([CH3:42])[CH3:43])[c:44]2[n:45][cH:46][cH:47][cH:48][c:49]2[n:50][n:51]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([N:14]2[CH2:15][c:16]3[cH:17][nH:18][c:19]4[n:20][cH:21][cH:22][c:23]([c:24]34)[C:25]2=[O:27])[CH2:11][CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 142844-(Dimethylamino)pyridineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 672243403-((1-(tert-butoxycarbonyl)piperidin-3-ylamino)methyl)-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid

Product 1

HCID 49841899tert-butyl 3-(5-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1H,3H,5H)-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-3ae286c1b4ba413c9c7e822cb2fa7b21
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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