反应详情

Diol 2.5 (5 g, 7 mmol) is dissolved in acetone (120 mL), 2,2-dimethoxypropane (20 mL), and pyridinium p-toluenesulfonate (120 mg, 0.5 mmol). The resulting solution is refluxed for 30 min., and then concentrated under reduced pressure to almost dryness. The resulting mixture is partitioned between methylene chloride and saturated NaHCO3 aqueous solution, dried, concentrated under reduced pressure, and purified by silica gel column chomatography to afford isopropylidene protected diol 2.6 (4.8 g, 92%).

1. temperatureThe resulting solution is refluxed for 30 min.
2. concentrationconcentrated under reduced pressure to almost dryness
3. customThe resulting mixture is partitioned between methylene chloride and saturated NaHCO3 aqueous solution
4. customdried
5. concentrationconcentrated under reduced pressure
6. custompurified by silica gel column chomatography