HCID 23155228, compound → HCID 58659408, compound

HRID 1993576Notes

Reaction equation

HRID 1993576 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]=[C:16]=[O:17])=[CH:11][CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:18][N:19]([CH2:21][C:22]1[CH:23]=[C:24]([NH2:32])[CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[CH3:20]>C1COCC1.CCOCC>[Cl:1][C:2]1[N:3]=[CH:4][N:5]=[C:6]([O:8][C:9]2[CH:10]=[CH:11][C:12]([NH:15][C:16]([NH:32][C:24]3[CH:25]=[C:26]([C:28]([F:29])([F:30])[F:31])[CH:27]=[C:22]([CH2:21][N:19]([CH3:20])[CH3:18])[CH:23]=3)=[O:17])=[CH:13][CH:14]=2)[CH:7]=1

Participants

5

Reactant 2

HCID 23155228HCID 23155228, compoundHCID 573517674-Chloro-6-(4-isocyanatophenoxy)pyrimidine

Product 1

HCID 58659408HCID 58659408, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 4-chloro-6-(4-isocyanato-phenoxy)-pyrimidine (Stage 135.1; 594 mg; 2.40 mmol) in THF (2 ml) is mixed under a N2-atmosphere with a solution of 3-dimethylaminomethyl-5-trifluoromethyl-phenylamine (Stage 135.2; 524 mg; 2.40 mmol) in ether (10 ml). Stirring at rt affords the title compound: MS: [M+1]+=466.

Sources & evidence

ORD record
ord-481dbb1ed6b146a1b7ddec2e404b250a
Source dataset
uspto-grants-2010_01
Patent number
US07652022B2

Reaction notes

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