反应详情

(4-Hydroxy-3-methyl-phenyl)-carbamic acid benzyl ester (278 mg, 1.08 mmol) and NaH (29 mg, 1.2 mmol) dissolved in DMF (5 mL) are stirred at rt for 15 min. 4,6-Dichloro-pyrimidine (177 mg, 1.19 mmol) dissolved in DMF (5 mL) is added and the reaction solution is stirred for 1 h, concentrated under reduced pressure and flash chromatographed (silica gel, 2.5×60 cm, AcOEt/hexane=1:6): M+H=370.8; Rf (AcOEt/hexane=1:6): 0.31.

1. additionis added
2. stirringthe reaction solution is stirred for 1 h
3. concentrationconcentrated under reduced pressure and flash
4. customchromatographed (silica gel, 2.5×60 cm, AcOEt/hexane=1:6)