反应详情

温度

70 °C

A mixture of 1-(2,5-dichloro-phenoxy)-2-fluoro-4-nitro-benzene (0.5 g, 1.7 mmol) and tin chloride (1.57 g, 8.3 mmol) in 30 ml of anhydrous ethanol was heated to 70° C. under argon and stirred for 4 hours. The solution was allowed to cool and then poured into ice. The solution was made slightly basic (pH 7-8) by addition of saturated aqueous sodium bicarbonate solution, then extracted with ethyl acetate. The organic phase was thoroughly washed with brine and dried treated with anhydrous sodium sulfate. Evaporation of the solvent left a yellow oily product which was used for the next step without further purification.

1. temperatureto cool
2. additionpoured into ice
3. extractionextracted with ethyl acetate
4. washThe organic phase was thoroughly washed with brine
5. customdried
6. additiontreated with anhydrous sodium sulfate
7. customEvaporation of the solvent
8. waitleft a yellow oily product which
9. customwas used for the next step without further purification