Isobutyryl chloride → N-[4-(5-Cyano-1-methyl-1H-pyrrol-2-yl)phenyl]-2-methylpropanamide

HRID 1993945Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH3:13])[C:11]([C:14]#[N:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:16](Cl)(=[O:20])[CH:17]([CH3:19])[CH3:18]>>[C:14]([C:11]1[N:12]([CH3:13])[C:8]([C:5]2[CH:6]=[CH:7][C:2]([NH:1][C:16](=[O:20])[CH:17]([CH3:19])[CH3:18])=[CH:3][CH:4]=2)=[CH:9][CH:10]=1)#[N:15]

Participants

Reactant 2

HCID 62325Isobutyryl chloride

HCID 160504305-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carbonitrile

Product 1

HCID 16037461N-[4-(5-Cyano-1-methyl-1H-pyrrol-2-yl)phenyl]-2-methylpropanamide

Procedure

The title compound was prepared according to the general procedure for acylation of 5-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carbonitrile using isobutyryl chloride (58 μL, 0.55 mmol) to provide N-[4-(5-cyano-1-methyl-1H-pyrrol-2-yl)phenyl]-2-methylpropanamide (0.026 g).

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-473f93b5f50e4a95a031891c0e4414aa
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07652062B2

Reaction notes

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