Ethanol → Ethyl 3-hydroxy-4-iodobenzoate

HRID 1994169Notes

Reaction equation

HRID 1994169 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[I:11])[C:5]([OH:7])=[O:6].[CH2:12](O)[CH3:13]>Cl>[CH2:12]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([I:11])=[C:2]([OH:1])[CH:3]=1)[CH3:13]

Participants

4

Reactant 2

HCID 702Ethanol2×HCID 7368543-Hydroxy-4-iodobenzoic acid

Product 1

HCID 11087596Ethyl 3-hydroxy-4-iodobenzoateYield 97%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Dissolve 3-hydroxy-4-iodobenzoic acid (2.02 g, 7.65 mmol) in ethanol saturated with HCl gas (50 ml). Heat the solution under reflux overnight. Evaporate ethanol to yield 3-Hydroxy-4-iodo-benzoic acid ethyl ester compound (97% yield).

Workup

  1. temperatureHeat the solution
  2. temperatureunder reflux overnight

Sources & evidence

ORD record
ord-12082c9ecff34a3aaa8ddbc3082354d4
Source dataset
uspto-grants-2010_01
Patent number
US07652064B2

Reaction notes

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