Hydrochloric Acid → HCID 178421680, compound

HRID 1995027Notes

Reaction equation

HRID 1995027 reaction equation
C(N[C:6](=[O:13])[C:7]([C:9]1([CH3:12])[CH2:11][CH2:10]1)=O)(C)(C)C.[NH2:14][NH:15][C:16]([NH:18][NH2:19])=[S:17].Cl.C(O)C>O>[NH2:14][N:15]1[C:6](=[O:13])[C:7]([C:9]2([CH3:12])[CH2:11][CH2:10]2)=[N:19][N:18]=[C:16]1[SH:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 2724189ThiocarbohydrazideHCID 20385839(1-Methylcyclopropyl)-glyoxylic acid tert-butylamide

Product 1

HCID 178421680HCID 178421680, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

183 g of (1-methylcyclopropyl)-glyoxylic acid tert-butylamide and 112 g of thiocarbohydrazide are added to a mixture of 1 liter of 1 N HCl and 1 liter of ethanol. The mixture is refluxed for 8 hours; it is subsequently cooled and diluted with 2 liters of H2O and the crystals are filtered off with suction. White crystals having a yellow lustre are obtained and these are dried.

Workup

  1. temperatureThe mixture is refluxed for 8 hours
  2. temperatureit is subsequently cooled
  3. filtrationthe crystals are filtered off with suction
  4. customare obtained
  5. customthese are dried

Sources & evidence

ORD record
ord-f365690b66db476589ec8909926f4fa5
Source dataset
uspto-grants-1983_09
Patent number
US04402733

Reaction notes

Loading…