Hydrochloric Acid → HCID 12952783, compound

HRID 1995077Notes

Reaction equation

HRID 1995077 reaction equation
[CH3:1][O:2][CH:3](OC)[CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[S:7].Cl.C(=O)([O-])O.[Na+]>>[CH3:1][O:2][CH:3]1[S:7][C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)[CH2:10][CH2:9]2)=[N:5][CH2:4]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 12952797HCID 12952797, compound

Product 1

HCID 12952783HCID 12952783, compoundYield 73%

Procedure

A mixture of 6 parts of N-(2,2-dimethoxyethyl)-4-(4-hydroxyphenyl)-1-piperazinecarbothioamide and 25 parts of a diluted hydrochloric acid solution is stirred overnight at room temperature. Upon the addition of sodium hydrogen carbonate, the product is allowed to crystallize. It is filtered off and recrystallized from ethanol, yielding 4.3 parts (73%) of 4-[4-(4,5-dihydro-5-methoxy-2-thiazolyl)-1-piperazinyl]phenol; mp. 165.6° C.

Workup

  1. customto crystallize
  2. filtrationIt is filtered off
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-bd383a8ef97a41dd8482c6d4c76b4184
Source dataset
uspto-grants-1983_09
Patent number
US04402957

Reaction notes

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