Potassium hydride → HCID 12799866, compound

HRID 1995090Notes

Reaction equation

HRID 1995090 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([O:13]CC)=O.[H-].[K+]>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11](=[O:13])[CH2:7][CH2:6][CH:5]1[CH2:4][CH2:3][CH2:2][NH:1][CH2:10]1

Participants

3

Reactant 2

HCID 82127Potassium hydrideHCID 421739ethyl quinoline-2-carboxylate

Product 1

HCID 12799866HCID 12799866, compoundYield 79.3%

Procedure

The operation is as in Example 1, starting from 14 g of ethyl quinoline-2-carboxylate, 17.4 g of ethyl 3-[3-(N-benzoyl)piperidyl]propionate and 36 ml of a 20% suspension of potassium hydride in oil. 7.4 g of 1-(2-quinolyl)-3-(3-piperidyl)-1-propanone are obtained, which is converted into its monohydrochloride. This monohydrochloride is recrystallized from ethanol. Its melting point, after recrystallization from ethanol, is 198° C.

Sources & evidence

ORD record
ord-714f5d85dd1b43b9b83e686b9e5d6ad4
Source dataset
uspto-grants-1983_09
Patent number
US04402961

Reaction notes

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