Potassium Hydroxide → HCID 12799867, compound

HRID 1995092Notes

Reaction equation

HRID 1995092 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11](=O)[CH2:12][CH2:13][CH:14]1[CH2:19][CH2:18][CH2:17][NH:16][CH2:15]1.O.NN.[OH-].[K+]>>[NH:16]1[CH2:17][CH2:18][CH2:19][CH:14]([CH2:13][CH2:12][CH2:11][C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)[CH2:15]1

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 12799866HCID 12799866, compound

Product 1

HCID 12799867HCID 12799867, compoundYield 26.4%

Procedure

The operation is as in Example 13, but starting from 6 g of 1-(2-quinolyl)-3-(3-piperidyl)-1-propanone, 6 ml of 85% hydrazine hydrate and 5 g of potassium hydroxide pellets. 4.9 g of crude product are obtained. This product is absorbed on a column of 150 g of silica and eluted with a 9/1 chloroform-diethylamine mixture. 1.5 g of 2-[3-(3-piperidyl)-propyl]-quinoline are thus obtained, which melts at 194° C.

Workup

  1. custom4.9 g of crude product are obtained
  2. customThis product is absorbed on a column of 150 g of silica
  3. washeluted with a 9/1 chloroform-diethylamine mixture

Sources & evidence

ORD record
ord-d87275a6c08b4b87bef0ff9e23c1c29c
Source dataset
uspto-grants-1983_09
Patent number
US04402961

Reaction notes

Loading…