Sulfur → 2-Fluoro-3'-methyl-1,1'-biphenyl

HRID 1995112Notes

Reaction equation

HRID 1995112 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][CH:12](O)[CH:11]=[C:10]([CH3:15])[CH2:9]1.[S]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:15])[CH:9]=1

Participants

3

Reactant 2

HCID 5362487SulfurHCID 128530402'-Fluoro-5-methyl-1,2,3,6-tetrahydro[1,1'-biphenyl]-3-ol

Product 1

HCID 128530412-Fluoro-3'-methyl-1,1'-biphenyl

Procedure

A mixture of 5-(2-fluorophenyl)-3-methyl-2-cyclohexen-1-ol (16.6 g, 0.08 mole) and sulfur (7.8 g, 0.24 mole) was heated at 180°-230° for 7.5 hours. The reaction mixture then stood at room temperature for approximately 60 hours before it was distilled under reduced pressure to give 2'-fluoro-3-methyl[1,1'-biphenyl].

Workup

  1. temperaturewas heated at 180°-230° for 7.5 hours
  2. distillationwas distilled under reduced pressure

Sources & evidence

ORD record
ord-12efdd4a6ae9429d8a0a0c5b9c27be05
Source dataset
uspto-grants-1983_09
Patent number
US04402973

Reaction notes

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