Triethylamine → HCID 13189017, compound

HRID 1995291Notes

Reaction equation

HRID 1995291 reaction equation
[CH2:1]1[CH2:6][NH:5][CH2:4][C:3]2[C:7](=[O:15])[O:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:2]1=2.C(N(CC)CC)C.Cl.Cl[CH2:25][CH2:26][N:27]1[CH2:33][CH:32]2[CH2:34][CH2:35][CH:29]([CH2:30][CH2:31]2)[CH2:28]1>>[CH:32]12[CH2:34][CH2:35][CH:29]([CH2:30][CH2:31]1)[CH2:28][N:27]([CH2:26][CH2:25][N:5]1[CH2:6][CH2:1][C:2]3[C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=4[O:8][C:7](=[O:15])[C:3]=3[CH2:4]1)[CH2:33]2

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 126123263-(2-Chloroethyl)-3-azabicyclo[3.2.2]nonane--hydrogen chloride (1/1)HCID 131369221,2,3,4-Tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-one

Product 1

HCID 13189017HCID 13189017, compoundYield 64.8%

Procedure

Prepared by the method described for Example 1 from 1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-one (1.5 g, 0.007 moles), triethylamine (2.2 ml, 0.016 moles), and 3-(2-chloroethyl)-3-azabicyclo[3.2.2]nonane hydrochloride (1.7 g, 0.0076 moles). Recrystallization from ethanol gave the product (1.6 g) as the monohydrochloride, 5:1 hydrate, mp 267° C. (dec).

Workup

  1. customPrepared by the method
  2. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-31b1463bd945480b8f147a5e7424cabe
Source dataset
uspto-grants-1983_09
Patent number
US04404138

Reaction notes

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