Triethylamine → HCID 13189022, compound

HRID 1995294Notes

Reaction equation

HRID 1995294 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[CH2:13][CH2:12][NH:11][CH2:10][C:9]=3[C:14](=[O:16])[O:15][C:4]=2[CH:3]=1.[CH2:17](N(CC)CC)[CH3:18].ClCC[C:27]12[CH2:35][CH2:34][CH:31]([CH2:32][CH2:33]1)[CH2:30][NH:29][CH2:28]2>>[CH:31]12[CH2:32][CH2:33][CH:27]([CH2:35][CH2:34]1)[CH2:28][N:29]([CH2:17][CH2:18][N:11]1[CH2:12][CH2:13][C:8]3[C:5]4[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][C:4]=4[O:15][C:14](=[O:16])[C:9]=3[CH2:10]1)[CH2:30]2

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 106087088-Methyl-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-oneHCID 86739020HCID 86739020, compound

Product 1

HCID 13189022HCID 13189022, compound

Procedure

Prepared by the method described for Example 13 from 1,2,3,4-tetrahydro-8-methyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one (2.0 g, 0.009 moles), triethylamine (3.1 ml, 0.022 moles), and 3-(2-chloroethyl-3-azabicyclo[3.2.2]nonane. Recrystallization from ethanol gave the product (1.7 g), mp 155°-157° C.

Workup

  1. customPrepared by the method
  2. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-642b7ea69d64475faca0d5ed55efc662
Source dataset
uspto-grants-1983_09
Patent number
US04404138

Reaction notes

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