Triethylamine → HCID 13189034, compound

HRID 1995304Notes

Reaction equation

HRID 1995304 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[CH2:13][CH2:12][NH:11][CH2:10][C:9]=3[C:14](=[O:16])[O:15][C:4]=2[CH:3]=1.C(N(CC)CC)C.Cl[CH2:25][CH2:26][N:27]1[CH2:34][CH:33]2[CH2:35][CH:29]([CH2:30][CH2:31][CH2:32]2)[CH2:28]1>>[CH:33]12[CH2:35][CH:29]([CH2:30][CH2:31][CH2:32]1)[CH2:28][N:27]([CH2:26][CH2:25][N:11]1[CH2:12][CH2:13][C:8]3[C:5]4[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][C:4]=4[O:15][C:14](=[O:16])[C:9]=3[CH2:10]1)[CH2:34]2

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 106087088-Methyl-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-oneHCID 144503123-(2-Chloroethyl)-3-azabicyclo[3.3.1]nonane

Product 1

HCID 13189034HCID 13189034, compoundYield 70.2%

Procedure

Prepared by the method described for Example 13 from 1,2,3,4-tetrahydro-8-methyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one (3.0 g, 0.014 moles), triethylamine (4.2 ml, 0.030 moles), and 3-(2-chloroethyl)-3-azabicyclo[3.3.1]nonane (3.3 g, 0.015 moles). The reflux time is 72 hours. Recrystallization from ethanol gave the product (3.6 g), mp 150°-152° C.

Workup

  1. customPrepared by the method
  2. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-98900ef4c1c64531836bbe0d7cae05dc
Source dataset
uspto-grants-1983_09
Patent number
US04404138

Reaction notes

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