Hydrazine hydrate (1:1) → HCID 20488255, compound

HRID 1995346Notes

Reaction equation

HRID 1995346 reaction equation
FC(F)(F)C=CC(OCC)=O.[F:12][C:13]([F:28])([F:27])[CH:14]([C:19](=O)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:15][C:16](O)=[O:17].O.[NH2:30][NH2:31]>>[C:20]1([C:19]2[CH:14]([C:13]([F:28])([F:27])[F:12])[CH2:15][C:16](=[O:17])[NH:30][N:31]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 141226Ethyl 4,4,4-trifluorobut-2-enoateHCID 20488259HCID 20488259, compound

Product 1

HCID 20488255HCID 20488255, compound

Procedure

In the same manner, reaction of α-phenyl-4-morpholinoacetonitrile with ethyl 3-trifluoromethylacrylate, followed by treatment of the resulting 3-trifluoromethyl-3-(benzoyl)propionic acid with hydrazine hydrate gives 6-phenyl-5-trifluoromethyl-4,5-dihydro-3(2H)-pyridazinone.

Sources & evidence

ORD record
ord-b658522f995e483ca8b15a12f544b362
Source dataset
uspto-grants-1983_09
Patent number
US04404203

Reaction notes

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