1,1'-Carbonyldiimidazole → HCID 178522656, compound

HRID 1995371Notes

Reaction equation

HRID 1995371 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[CH:5]=[CH:4][CH:3]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH2:23][C:24]1[NH:28][N:27]=[N:26][N:25]=1>>[NH:25]1[C:24]([NH:23][C:8]([C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([Br:1])[N:7]=2)=[O:10])=[N:28][N:27]=[N:26]1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 5939196-Bromopyridine-2-carboxylic acidHCID 178509299HCID 178509299, compound

Product 1

HCID 178522656HCID 178522656, compoundYield 56.5%

Procedure

0.89 g of 6-bromo-2-pyridinecarboxylic acid, 0.71 g of N,N-carbonyldiimidazole and 0.41 g of 5-aminotetrazole are treated in the same manner as described in Example 2. The crude product thus obtained is recrystallized from a mixture of dimethylformamide and water, whereby 0.67 g of N-(5-tetrazolyl)-6-bromo-2-pyridinecarboxamide is obtained.

Workup

  1. customThe crude product thus obtained
  2. customis recrystallized from a mixture of dimethylformamide and water

Sources & evidence

ORD record
ord-2d999320cedb49fd885411f619045b1b
Source dataset
uspto-grants-1983_09
Patent number
US04404214

Reaction notes

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