2,4-Dichlorophenol → 2-(2,4-dichlorophenoxy)-1-phenylethanone

HRID 1995450Notes

Reaction equation

HRID 1995450 reaction equation
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].[Na].[K].[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1[OH:21]>[Cu]>[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1[O:21][CH2:9][C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1)=[O:10]

Participants

6

Reactant 4

HCID 84492,4-DichlorophenolHCID 72864Ethanone, 1-(2-chlorophenyl)-HCID 5360545SodiumHCID 5462222Potassium

Product 1

HCID 29820232-(2,4-dichlorophenoxy)-1-phenylethanone

Reagents, catalysts & solvents 1

HCID 23978CopperCatalyst

Procedure

Hitherto this compound has been prepared by reacting o-chloroacetophenone with the sodium or potassium salt of 2,4-dichlorophenol at a temperature of at least 120° C. in the presence of a copper catalyst to produce 2-(2,4-dichlorophenoxy)acetophenone. This is then reacted with sulphur and morpholine to afford a thioacetmorpholide which is thereafter hydrolysed.

Workup

  1. customHitherto this compound has been prepared
  2. customat a temperature of at least 120° C.

Sources & evidence

ORD record
ord-3d4b214e08dd4721ba8d74e862824c8a
Source dataset
uspto-grants-1983_09
Patent number
US04404396

Reaction notes

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