Hydrochloric Acid → HCID 13218906, compound

HRID 1995457Notes

Reaction equation

HRID 1995457 reaction equation
S([O-])([O-])=O.[Na+].[Na+].F[S:8]([C:11]1[CH:17]=[C:16]([Br:18])[CH:15]=[C:14]([Br:19])[C:12]=1[NH2:13])(=[O:10])=[O:9].Cl>O>[NH2:13][C:12]1[C:14]([Br:19])=[CH:15][C:16]([Br:18])=[CH:17][C:11]=1[S:8]([OH:10])=[O:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24437Sodium SulfiteHCID 132189042-Amino-3,5-dibromobenzene-1-sulfonyl fluoride

Product 1

HCID 13218906HCID 13218906, compoundYield 79.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of sodium sulfite (Na2SO3 ; 20.2 g; 0.16 mol) and water (100 ml) is stirred and heated to 70° C. and 2-fluorosulfonyl-4,6-dibromoaniline (13.3 g; 0.04 mol) is added at once. The reaction mixture cools down somewhat and is reheated to 70° C. and maintained at that temperature for 20 hours. The reaction mixture is then cooled down, acidifed with 10% hydrochloric acid to yield a white precipitate. The precipitate is filtered, washed with water and dried to afford 10 g of title product, m.p. 112° C. (decomposed).

Workup

  1. customis reheated to 70° C.
  2. temperaturemaintained at that temperature for 20 hours
  3. temperatureThe reaction mixture is then cooled down
  4. customto yield a white precipitate
  5. filtrationThe precipitate is filtered
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-e54fa32ba2494953a21dbbca795e89a1
Source dataset
uspto-grants-1983_09
Patent number
US04404402

Reaction notes

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