Hydrochloric Acid → 79416-28-7

HRID 1995582Notes

Reaction equation

HRID 1995582 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([NH:12][C@H:13]([CH2:18][OH:19])[CH2:14][CH2:15][S:16][CH3:17])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:27]>O1CCOCC1>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([CH2:18][OH:19])[CH2:14][CH2:15][S:16][CH3:17])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131713085HCID 131713085, compound

Product 1

HCID 1280037979416-28-7

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 21.1 g Boc-Phe-Met-ol in 20 ml dioxane is added at 0° C. to 130 ml 5 N HCl in dioxane. After reaction for 1 hour at 0° C., 400 ml ethyl ester are added, the precipitate filtered under suction, washed with ethyl ether and dried over P2O5 and KOH under vacuum, to yield the title compound: [α]D20 =+8.8° (c=1 in DMF), decomposition at 200° C.

Workup

  1. customAfter reaction for 1 hour at 0° C.
  2. filtrationthe precipitate filtered under suction
  3. washwashed with ethyl ether
  4. dry with materialdried over P2O5 and KOH under vacuum

Sources & evidence

ORD record
ord-e292a1985fe54b4fa78c839f71f37331
Source dataset
uspto-grants-1983_09
Patent number
US04405607

Reaction notes

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