2,6-Dichlorobenzoyl isocyanate → 1-(2,6-Dichlorobenzoyl)-3-(6-methyl-5-phenyl-2-pyridyl)urea

HRID 1995609Notes

Reaction equation

HRID 1995609 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[CH3:14][C:15]1[N:20]=[C:19]([NH2:21])[CH:18]=[CH:17][C:16]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(OCC)(=O)C>[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([NH:6][C:7]([NH:21][C:19]1[CH:18]=[CH:17][C:16]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:15]([CH3:14])[N:20]=1)=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 129127392,6-Dichlorobenzoyl isocyanateHCID 135028556-Methyl-5-phenylpyridin-2-amine

Product 1

HCID 132426501-(2,6-Dichlorobenzoyl)-3-(6-methyl-5-phenyl-2-pyridyl)urea

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2,6-Dichlorobenzoyl isocyanate (650 mg) was reacted with 6-methyl-5-phenyl-2-pyridylamine (500 mg) in 25 ml of ethyl acetate. A precipitate formed which was filtered and confirmed by NMR as the desired product, 219°-220° C.

Workup

  1. customA precipitate formed which
  2. filtrationwas filtered
  3. customconfirmed by NMR as the desired product, 219°-220° C.

Sources & evidence

ORD record
ord-59a857496e0e4bd2814e14ecedbe41cc
Source dataset
uspto-grants-1983_09
Patent number
US04405552

Reaction notes

Loading…