Glycidol → 3-(4-Hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)propane-1,2-diol

HRID 1995728Notes

Reaction equation

HRID 1995728 reaction equation
[CH3:1][C:2]1([CH3:11])[CH2:7][CH:6]([OH:8])[CH2:5][C:4]([CH3:10])([CH3:9])[NH:3]1.[CH2:12]1[O:14][CH:13]1[CH2:15][OH:16]>C(O)(C)C>[OH:14][CH:13]([CH2:15][OH:16])[CH2:12][N:3]1[C:4]([CH3:10])([CH3:9])[CH2:5][CH:6]([OH:8])[CH2:7][C:2]1([CH3:11])[CH3:1]

Participants

4

Reactant 2

HCID 11164GlycidolHCID 754714-Hydroxy-2,2,6,6-tetramethylpiperidine

Product 1

HCID 204878043-(4-Hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)propane-1,2-diol

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2,2,6,6-Tetramethyl-4-piperidinol 15.7 g and glycidol 7.8 g were dissolved in 50 ml of isopropanol and refluxed for five hours. Isopropanol was distilled off and the residue was recrystallized from n-hexane. A white powder, 21.3 g m.p. 97° to 99° C., was obtained.

Workup

  1. temperaturerefluxed for five hours
  2. distillationIsopropanol was distilled off
  3. customthe residue was recrystallized from n-hexane
  4. customA white powder, 21.3 g m.p. 97° to 99° C., was obtained

Sources & evidence

ORD record
ord-b6b35d2159834948b0534c6b9ac190f1
Source dataset
uspto-grants-1983_09
Patent number
US04405737

Reaction notes

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