Triethylamine → HCID 20487950, compound

HRID 1995743Notes

Reaction equation

HRID 1995743 reaction equation
Cl.[C:2]([CH:6]1[CH:11]2[CH2:12][CH:8]([CH2:9][CH2:10]2)[NH:7]1)([O:4][CH3:5])=[O:3].[C:13]([CH2:18][CH2:19][C:20](Cl)=[O:21])([O:15][CH2:16][CH3:17])=[O:14].C(N(CC)CC)C>CC(C)=O>[C:13]([CH2:18][CH2:19][C:20]([N:7]1[CH:6]([C:2]([O:4][CH3:5])=[O:3])[CH:11]2[CH2:12][CH:8]1[CH2:9][CH2:10]2)=[O:21])([O:15][CH2:16][CH3:17])=[O:14]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 84648Butanoic acid, 4-chloro-4-oxo-, ethyl esterHCID 20487957Methyl 2-azabicyclo[2.2.1]heptane-3-carboxylate hydrochloride

Product 1

HCID 20487950HCID 20487950, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Using the method of Example 1, 4.45 g (0.0232 m) of 3-carbomethoxy-2-azabicyclo[2.2.1]heptane hydrochloride and 3-carbethoxypropanoyl chloride were reacted using triethylamine and acetone to give 4.59 g of syrupy 2-(3-carbethoxypropanoyl)-3-carbomethoxy-2-azabicyclo[2.2.1]heptane.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-29423cf371da479e802f4287a69f04b3
Source dataset
uspto-grants-1983_09
Patent number
US04405787

Reaction notes

Loading…