Hydrochloric Acid → HCID 3062241, compound

HRID 1995757Notes

Reaction equation

HRID 1995757 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[CH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.[OH-].[Na+].Cl.[CH:21](Cl)(Cl)[Cl:22]>[Cl-].C([N+](CC)(CC)CC1C=CC=CC=1)C.O>[Cl:22][C:21]1[C:2]([CH2:10][CH2:11][CH:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)=[N:1][C:9]2[C:4]([CH:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 12805990HCID 12805990, compound

Product 1

HCID 3062241HCID 3062241, compound

Reagents, catalysts & solvents 2

HCID 66133Benzyl triethylammonium chlorideCatalystHCID 962WaterSolvent

Procedure

The operation is as in Example 1, but starting from 8.3 g of 4-[2-(2-indolyl)-ethyl]-piperidine and 0.18 g of triethylbenzylammonium chloride in 90 ml of chloroform, and 11 g of sodium hydroxide in solution in 22 ml of water. 1.45 g of 3-chloro-2-[2-(4-piperidyl)-ethyl]-quinoline are obtained the monohydrochloride of which melts at 162° C.

Sources & evidence

ORD record
ord-9745302f843e4e68b74547c399d8f678
Source dataset
uspto-grants-1983_09
Patent number
US04405789

Reaction notes

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