Methyl iodide → HCID 54270203, compound

HRID 1995812Notes

Reaction equation

HRID 1995812 reaction equation
[C:1]([O:7][CH2:8][CH3:9])(=S)[NH:2]C(N)=O.[C:10](OC)(=[S:15])[NH:11][C:12]([NH2:14])=[O:13].[CH2:18](Br)[CH3:19].CI.[C:23]1([CH3:32])[CH:28]=[CH:27][C:26](N=C=O)=[CH:25][CH:24]=1.ClC1C=C(Cl)C=CC=1N=C=[O:43]>>[CH2:8]([O:7][C:1]([N:2]=[C:10]([S:15][CH2:18][CH3:19])[NH:11][C:12](=[O:13])[NH:14][C:26]1[CH:27]=[CH:28][C:23]([CH3:32])=[CH:24][CH:25]=1)=[O:43])[CH3:9]

Participants

7

Reactant 6

HCID 6328Methyl iodideHCID 6332Ethyl BromideHCID 693254-Methylphenyl isocyanateHCID 757892,4-Dichlorophenyl isocyanateHCID 54333945HCID 54333945, compoundHCID 54493048HCID 54493048, compound

Product 1

HCID 54270203HCID 54270203, compoundYield 81%

Procedure

The procedure described in Example 2 was repeated, except that 1.48 g of ethyl thioallophanate were used in place of the methyl thioallophanate, 1.3 g of ethyl bromide were used in place of the methyl iodide and 1.33 g of p-tolyl isocyanate were used in place of the 2,4-dichlorophenyl isocyanate. 2.5 g (yield 81%) of the desired compound were obtained in the form of colourless prisms having a melting point of 110°-112° C.

Sources & evidence

ORD record
ord-7a8ad13a7dc7462084f1b132b42ecbe1
Source dataset
uspto-grants-1983_09
Patent number
US04406687

Reaction notes

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