Sodium Hydroxide → 2,6-Difluorobenzonitrile
Reaction equation
Cl[C:2]1[C:3]([F:11])=[C:4]([C:7]([F:10])=[CH:8][CH:9]=1)[C:5]#[N:6].[OH-].[Na+]>[C].[Pd].O>[F:10][C:7]1[CH:8]=[CH:9][CH:2]=[C:3]([F:11])[C:4]=1[C:5]#[N:6]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
In the same manner as in the process of the reduction step of Example 1, the reaction was carried out at 40° C. for 2.5 hours by using 10 g of 3-chloro-2,6-difluorobenzonitrile, 60 g of water, 0.25 g of palladium-carbon catalyst and 3 g of sodium hydroxide, and refinement was carried out to obtain 5.63 g of 2,6-difluorobenzonitrile.
Sources & evidence
- ORD record
- ord-34571d0dd3b448d0b9dc8cef745087d1
- Source dataset
- uspto-grants-1983_09
- Patent number
- US04406841
Reaction notes
Loading…