Dimethyl Sulfate → 5-Bromo-7-fluoro-2-methyl-2H-indazole

HRID 1996149Notes

Reaction equation

HRID 1996149 reaction equation
[CH3:1]OS(OC)(=O)=O.[F:2][c:3]1[c:12]([c:8]2[cH:7][c:5]([Br:6])[cH:4]1)[nH:11][n:10][cH:9]2>>[CH3:1][n:10]1[n:11][c:12]([c:8]2[cH:9]1)[c:3]([F:2])[cH:4][c:5]([Br:6])[cH:7]2

Participants

6

Reactant 2

HCID 6497Dimethyl SulfateHCID 667931105-Bromo-7-fluoro-1H-indazole

Product 1

HCID 1225445725-Bromo-7-fluoro-2-methyl-2H-indazole

Reagents, catalysts & solvents 3

HCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineReagentHCID 8028TetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-57ce8df0562841218bb6590b840453dc
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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