tert-Butyl 3-amino-3-methylpyrrolidine-1-carboxylate → Tert-butyl 3-(4-chloro-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl)-3-methylpyrrolidine-1-carboxylate

HRID 1996398Notes

Reaction equation

HRID 1996398 reaction equation
CS(O[CH2:1][CH2:2][c:3]1[c:9](Cl)[n:8][c:7]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[n:6][c:4]1[Cl:5])(=O)=O.[CH3:16][C:17]([O:20][C:21]([N:23]1[CH2:29][C:26]([NH2:28])([CH3:27])[CH2:25][CH2:24]1)=[O:22])([CH3:19])[CH3:18]>>[CH3:16][C:17]([O:20][C:21]([N:23]1[CH2:29][C:26]([N:28]2[c:9]([c:3]3[CH2:2][CH2:1]2)[n:8][c:7]([N:10]4[CH2:15][CH2:14][O:13][CH2:12][CH2:11]4)[n:6][c:4]3[Cl:5])([CH3:27])[CH2:25][CH2:24]1)=[O:22])([CH3:19])[CH3:18]

Participants

6

Reactant 2

HCID 57415917tert-Butyl 3-amino-3-methylpyrrolidine-1-carboxylateHCID 178505284HCID 178505284, compound

Product 1

HCID 123726091Tert-butyl 3-(4-chloro-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl)-3-methylpyrrolidine-1-carboxylate

Reagents, catalysts & solvents 3

HCID 22031701Potassium phosphate, tribasic, monohydrateReagentHCID 8028TetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
120 °C

Sources & evidence

ORD record
ord-868ff4c354b44b3085e6cd23b4a6759a
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

Loading…