tert-Butyl 3-amino-3-methylpyrrolidine-1-carboxylate → Tert-butyl 3-(4-chloro-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl)-3-methylpyrrolidine-1-carboxylate

HRID 1996399Notes

Reaction equation

HRID 1996399 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:14][C:11]([NH2:13])([CH3:12])[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].CS(O[CH2:15][CH2:16][c:17]1[c:23](Cl)[n:22][c:21]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[n:20][c:18]1[Cl:19])(=O)=O>>[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:14][C:11]([N:13]2[c:23]([c:17]3[CH2:16][CH2:15]2)[n:22][c:21]([N:24]4[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)[n:20][c:18]3[Cl:19])([CH3:12])[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3]

Participants

6

Reactant 2

HCID 57415917tert-Butyl 3-amino-3-methylpyrrolidine-1-carboxylateHCID 178505284HCID 178505284, compound

Product 1

HCID 123726091Tert-butyl 3-(4-chloro-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl)-3-methylpyrrolidine-1-carboxylate

Reagents, catalysts & solvents 3

HCID 25953Cesium fluorideReagentHCID 64052-Methyl-2-butanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
120 °C

Sources & evidence

ORD record
ord-e1908317e7a94359b59c024e30e78245
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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