Potassium Carbonate → HCID 22446281, compound

HRID 1998Notes

Reaction equation

HRID 1998 reaction equation
[CH2:1]([O:3][CH2:4][N:5]1[C:14](=[O:15])[C:13]2[NH:12][CH:11]=[N:10][C:9]=2[NH:8][C:6]1=[O:7])[CH3:2].[C:16](=O)([O-])[O-].[K+].[K+].Cl[CH:23]([P:27]([O:32][CH2:33][CH3:34])(=[O:31])[O:28][CH2:29][CH3:30])[CH2:24][CH2:25][CH3:26]>>[CH2:1]([O:3][CH2:4][N:5]1[C:14](=[O:15])[C:13]2[N:12]([CH2:26][CH2:25][CH2:24][CH2:23][P:27](=[O:31])([O:32][CH2:33][CH3:34])[O:28][CH2:29][CH3:30])[CH:11]=[N:10][C:9]=2[N:8]([CH3:16])[C:6]1=[O:7])[CH3:2]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 14665078Diethyl chlorobutanephosphonateHCID 19689203HCID 19689203, compound

Product 1

HCID 22446281HCID 22446281, compound

Procedure

4 g (0.018 mol) of 1-ethoxymethylxanthine were stirred at 70° C. for 6 hours with 3 g of potassium carbonate and 4.9 g (0.0214 mol) of diethyl chlorobutanephosphonate. The solution was filtered and concentrated, and the residue which remained was chromatographed (eluent: dichloromethane/methanol 20:1).

Workup

  1. filtrationThe solution was filtered
  2. concentrationconcentrated
  3. customthe residue which remained was chromatographed (eluent: dichloromethane/methanol 20:1)

Sources & evidence

ORD record
ord-8750cc7ad61a432da65104ddaeebb4b3
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Reaction notes

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